The guidelines emphasize lifestyle modifications (Mediterranean diet & physical activity), along with pharmacological measures, including blood pressure management, antiplatelet therapy, and glucagon-like protein-1 receptor agonists for diabetes and cardiovascular risk reduction. Screening and addressing specific risks (pregnancy-related complications, endometriosis) are essential for comprehensive stroke prevention.

A study reveals that individuals with headache disorders, including migraine and posttraumatic headache, face significantly higher suicide risk. The 15-year absolute risk for attempted suicide was 0.45% higher in headache sufferers vs. non-sufferers. Hazard ratios for attempted and completed suicide were 2.04 and 1.40, with trigeminal autonomic cephalalgia and posttraumatic headache showing the strongest association.

A newly developed nomogram accurately predicts survival in ICU patients with acute kidney injury (AKI). Incorporating various factors, the model demonstrated strong accuracy with AUC values of 0.827, 0.799, and 0.777 for 1-, 3-, and 5-year survival in the training dataset. Survival outcomes also varied with medication use, suggesting that the nomogram can aid clinical decision-making.

Older adults with involutional ectropion experience a 4-times higher risk of blepharitis (OR 4.66), and a 2-times higher risk of chalazion (OR 2.94), hordeolum (OR 2.26), and pterygium (OR 2.48), among others. They also face a 43-46% increased risk of systemic diseases like hypertension, dyslipidemia, and autoimmune rheumatic disorders, suggesting link between local & systemic factors in the development of ectropion.

A study highlighted that age plays a key role in hepatocellular carcinoma (HCC) development after HCV cure with direct-acting antivirals. Patients with non-cirrhosis and low fibrosis (FIB-4<1.45) showed no HCC, while older patients with moderate-advanced fibrosis (FIB-4≥3.25) had higher risks. Metabolic factors like BMI and diabetes did not impact HCC development, and recurrences occurred within 5 years of HCV cure.